Tours from Los Angeles to San Francisco head north on Highway 1, through Santa Barbara, Solvang, Hearst Castle and Big Sur to Carmel, Monterey and the 17-Mile Drive. Some end in San Francisco, and others loop back to Los Angeles through Yosemite, Las Vegas or the Grand Canyon. Hotels and transport are included. Starting in San Francisco instead? See Los Angeles tours from San Francisco.
The fast way is Interstate 5 through the Central Valley, about six hours with little to see. Most tours take the coast instead, following Highway 1 past Santa Barbara, Solvang, San Simeon and Big Sur, then Carmel, Monterey and the 17-Mile Drive before reaching San Francisco. The coastal route takes a full day or more, which is why these trips run over several days with hotels on the way.
Yosemite sits inland, about four hours east of San Francisco, so routes that include it add at least a day and swap some coastal stops for Yosemite Valley, El Capitan and the waterfalls. Choose it if you want both the coast and a national park in one trip. In winter some high roads in the park close, but Yosemite Valley stays open and tours still visit.
Most routes give San Francisco a half day to a full day, covering the Golden Gate Bridge, Fisherman's Wharf, Lombard Street and Union Square. Alcatraz is usually not included and its tickets sell out weeks ahead, so book it yourself early if it matters to you. If you want more time in the city, check whether your tour ends in San Francisco or returns to Los Angeles.